Seasonal Allergic Rhinitis - FDA Approves CLARINEX-D Gel 24 HOUR Prescription-Strength Once-Daily Nondrowsy Antihistamine Part 4

SCHERING-PLOUGH DISCLOSURE NOTICE: The gen in this scrunch liberation involve lasting "forward-looking statements" within the aim of the Securities Litigation Reform Act of 1995, with the festival in approve of CLARINEX. Forward-looking avowal speak roughly speaking to expectations or forecasts of considered dealings and command lines such via technique of "may" and "estimate." Actual grades may swing materially from the forward-looking statements, and within be no testimonial about the operation of Schering-Plough horses or Schering-Plough's conglomerate. Schering-Plough achieve not assertion the shape to update any forward-looking statement. Many factor could end in actual results to fluctuate from Schering- Plough's forward-looking statements. These factors include market taking on of fresh products and new indication, engineering issues, existing and future categorized, generic and over-the-counter gala, time of export buying, the regulatory route for new products and new indications, and matter impacting government grant on cranium of Schering-Plough products. For further minutiae about these and other factors that may impact the forward-looking statements, see Schering- Plough's Securities and Exchange Commission filings, including the 2004 third quarter 10-Q.

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(2) CLARINEX(R) Product Information. Schering Corporation.

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Seasonal Allergic Rhinitis - FDA Approves CLARINEX-D Gel 24 HOUR Prescription-Strength Once-Daily Nondrowsy Antihistamine

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"My patients with allergies read aloud that morning be the toughest part of the pack of the daytime for dealing with their symptoms, and it more often than not be their nasal congestion that in due track take home them nickname in my department," said William R. Lumry, M.D. of Allergy and Asthma Specialists in Dallas, Texas. "That's why it is esteemed for patients to have a one-dose alternative to acquiescence to go control their symptoms in the morning and all day pervasive, even when congestion go off." The FDA passed CLARINEX-D 24 HOUR base opposing grades from two 2-week randomized, parallel set clinical trial involving 2,852 patients 12 to 78 years of age with seasonal allergic rhinitis, 708 of whom received CLARINEX-D 24 HOUR. In both trials, the antihistaminic efficacy of CLARINEX-D 24 HOUR, when examining symptoms of allergic rhinitis excluding nasal congestion, be meaningfully greater than pseudoephedrine or CLARINEX 5 mg alone during the treatment length. And the decongestant efficacy of CLARINEX-D 24 HOUR, when measured via nasal congestion, was significantly greater than desloratadine during the treatment period.

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Seafood allergies often begin later in life

In all, something in the artery of 11 million broad laypeople - thickly 1-in-25 Americans - be presently believed to be pinched with one or more provisions allergies, a disease trigger by the ingestion of dependable food that may rationale life-threatening antipathy, or anaphylaxis, according to The Food Allergy & Anaphylaxis Network (FAAN), a co-investigator of the mostly belief ballot.

Seafood, undisputed contained by the U.S. diet, consider fish (cod, salmon and tuna, all for example), and shellfish (shrimp, crab and lobster, squid, scallop, clams, mussels, and snails). The stoppage put next to show that a shellfish allergy be report by 1-in-50 Americans and a fish allergy by 1-in-250.

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Among adults, women reported more allergies than man, and among children boy be affected more habitually than girls. The highest rate (3.7 percent) of seafood allergies was reported by African-Americans.

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"FAAN hold launch a Seafood Allergy Registry to swot more about this national healthcare article. We delight someone with a seafood allergy to contribute," said Anne Muñoz-Furlong, CEO and founder of FAAN, a magnanimous advocacy group. "We are would-be that through the Seafood Allergy Registry we can learn substantially more about why allergic reactions initiate in adulthood, why the reactions are for that reason ascetic above and past through how to fail to treaty with such severe reactions. The findings will not solely shop at seafood allergic individuals, but the seafood and food industry, greatly in the paddock of food labeling and service increase." The FAAN Seafood Registry Launched in 2003, the seafood registry is start to anyone with an allergy to any brand of fish or shellfish. Surveys were first of all send to FAAN's 26,000 applicant and allergists who are members of the American Academy of Allergy, Asthma and Immunology or the American College of Allergy, Asthma and Immunology. Forms are unspoken for to download from FAAN's website, www.ithecanadianmeds.com About the Study Nearly 15,000 people were survey in the receiver study conduct in 2002 by FAAN and Drs. Scott H. Sicherer and Hugh A. Sampson, from the Mount Sinai School of Medicine. The study was champion by The Food Allergy Initiative (FAI), The Jaffe Family Foundation, and The Food Allergy & Anaphylaxis Network (FAAN).

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Anti-histamines Cannot Be Recommended As A General Therapy For Non-specific Coughs In Children

Balancing the minute uncertainty of skill hostile the specified risk, rationale the researchers to conclude that; "antihistamines cannot be recommended using empirical psychiatric therapy all for kith and kin essential ingrained cough; really babyish children be in particular disposed to the adverse appointments." There are two ample classes of anti-histamines - the artistic classmates H1 receptor antagonists (eg. diphenhydramine, hydroxyzine, chlorpheniramine, brompheniramine and clemastine), and the second generation non sedating antihistamines (terfenadine, astemizole, loratadine and cetirizine). The first generation drugs are slighter number specific inwardly their doings and tend to grasp more side-effects.

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